One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction
نویسندگان
چکیده
A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides. The three-component coupling proceeds through the Groebke-Blackburn-Bienaymé reaction followed by a retro-aza-ene reaction and subsequent nucleophilic reaction of the in-situ generated imidazo[1,2-a]pyridines bearing an isocyanate functional group.
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2016